Name	Flags	Card.	Type	Description & Constraints
Condition	C	0..*	Condition	Detailed information about conditions, problems or diagnoses con-2: If category is problems list item, the clinicalStatus should not be unknown con-3: If condition is abated, then clinicalStatus must be either inactive, resolved, or remission. dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated dom-5: If a resource is contained in another resource, it SHALL NOT have a security label dom-6: A resource should have narrative for robust management
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created ele-1: All FHIR elements must have a @value or children
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
extension:due-to	S	0..1	Reference(Tumor Pathology Event)	The parent tumoral event URL: http://hl7.org/fhir/StructureDefinition/condition-dueTo profiled by http://ltsi.univ-rennes.fr/StructureDefinition/dueTo-tumor-pathology-event ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
extension:laterality	S	0..1	CodeableConcept	Laterality of location URL: http://ltsi.univ-rennes.fr/StructureDefinition/laterality Binding: Tumor Laterality Value Set (required) ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
extension:histologygrade	S	0..1	(Complex)	Histology of the tumor URL: http://ltsi.univ-rennes.fr/StructureDefinition/histologygrade ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
clinicalStatus	?!ΣC	1..1	CodeableConcept	active | recurrence | relapse | inactive | remission | resolved | unknown Binding: ConditionClinicalStatusCodes (required): The clinical status of the condition or diagnosis. ele-1: All FHIR elements must have a @value or children
verificationStatus	?!Σ	0..1	CodeableConcept	unconfirmed | provisional | differential | confirmed | refuted | entered-in-error Binding: ConditionVerificationStatus (required): The verification status to support or decline the clinical status of the condition or diagnosis. ele-1: All FHIR elements must have a @value or children
code	SΣ	1..1	CodeableConcept	Type of tumor event Binding: Tumor Pathology Event Type Value Set (required) ele-1: All FHIR elements must have a @value or children
bodySite	SΣ	1..1	CodeableConcept	Topographic code Binding: Topography Value Set (extensible) ele-1: All FHIR elements must have a @value or children
subject	SΣ	1..1	Reference(OncoFAIR Patient)	Who has the condition? ele-1: All FHIR elements must have a @value or children
Slices for onset[x]	Σ	1..1	dateTime	Estimated or actual date, date-time, or age Slice: Unordered, Closed by type:$this ele-1: All FHIR elements must have a @value or children
onset[x]:onsetDateTime	SΣ	1..1	dateTime	Start date ele-1: All FHIR elements must have a @value or children
Slices for abatement[x]	C	0..1	dateTime	When in resolution/remission Slice: Unordered, Closed by type:$this ele-1: All FHIR elements must have a @value or children
abatement[x]:abatementDateTime	SC	0..1	dateTime	End date ele-1: All FHIR elements must have a @value or children
recordedDate	SΣ	1..1	dateTime	Date of diagnosis ele-1: All FHIR elements must have a @value or children
Slices for stage	C	1..*	BackboneElement	Stage/grade, usually assessed formally Slice: Unordered, Open by pattern:type.coding.code con-1: Stage SHALL have summary or assessment ele-1: All FHIR elements must have a @value or children
stage:All Slices				Content/Rules for all slices
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
stage:morphology	SC	1..1	BackboneElement	International code of lesion / histological type / morphology of the tumoral event con-1: Stage SHALL have summary or assessment ele-1: All FHIR elements must have a @value or children
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
summary	C	1..1	CodeableConcept	Histological/ morphological code Binding: Morphology Value Set (extensible) ele-1: All FHIR elements must have a @value or children
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet	URI
Condition.clinicalStatus	required	ConditionClinicalStatusCodes http://hl7.org/fhir/ValueSet/condition-clinical|5.0.0 from the FHIR Standard
Condition.verificationStatus	required	ConditionVerificationStatus http://hl7.org/fhir/ValueSet/condition-ver-status|5.0.0 from the FHIR Standard
Condition.code	required	TumorPathologyEventType http://ltsi.univ-rennes.fr/ValueSet/TumorPathologyEventType from this IG
Condition.bodySite	extensible	Topography http://ltsi.univ-rennes.fr/ValueSet/Topography from this IG
Condition.stage:morphology.summary	extensible	Morphology http://ltsi.univ-rennes.fr/ValueSet/Morphology from this IG

Constraints

Id	Grade	Path(s)	Details	Requirements
con-1	error	Condition.stage, Condition.stage:morphology	Stage SHALL have summary or assessment : summary.exists() or assessment.exists()
con-2	warning	Condition	If category is problems list item, the clinicalStatus should not be unknown : category.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-category' and code='problem-list-item').exists() implies clinicalStatus.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-clinical' and code='unknown').exists().not()
con-3	error	Condition	If condition is abated, then clinicalStatus must be either inactive, resolved, or remission. : abatement.exists() implies (clinicalStatus.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-clinical' and (code='inactive' or code='resolved' or code='remission')).exists())
dom-2	error	Condition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	Condition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	Condition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	Condition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	Condition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Name	Flags	Card.	Type	Description & Constraints
Condition			Condition
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:due-to	S	0..1	Reference(Tumor Pathology Event)	The parent tumoral event URL: http://hl7.org/fhir/StructureDefinition/condition-dueTo profiled by http://ltsi.univ-rennes.fr/StructureDefinition/dueTo-tumor-pathology-event
extension:laterality	S	0..1	CodeableConcept	Laterality of location URL: http://ltsi.univ-rennes.fr/StructureDefinition/laterality Binding: Tumor Laterality Value Set (required)
extension:histologygrade	S	0..1	(Complex)	Histology of the tumor URL: http://ltsi.univ-rennes.fr/StructureDefinition/histologygrade
code	S	1..1	CodeableConcept	Type of tumor event Binding: Tumor Pathology Event Type Value Set (required)
bodySite	S	1..1	CodeableConcept	Topographic code Binding: Topography Value Set (extensible)
subject	S	1..1	Reference(OncoFAIR Patient)	Who has the condition?
Slices for onset[x]		1..1	dateTime	Estimated or actual date, date-time, or age Slice: Unordered, Open by type:$this
onset[x]:onsetDateTime	S	1..1	dateTime	Start date
Slices for abatement[x]		0..1	dateTime	When in resolution/remission Slice: Unordered, Open by type:$this
abatement[x]:abatementDateTime	S	0..1	dateTime	End date
recordedDate	S	1..1	dateTime	Date of diagnosis
Slices for stage		1..*	BackboneElement	Stage/grade, usually assessed formally Slice: Unordered, Open by pattern:type.coding.code
stage:morphology	S	1..1	BackboneElement	International code of lesion / histological type / morphology of the tumoral event
summary		1..1	CodeableConcept	Histological/ morphological code Binding: Morphology Value Set (extensible)
type
coding
code		1..1	code	Symbol in syntax defined by the system Required Pattern: 116676008
Documentation for this format

Terminology Bindings (Differential)

Path	Conformance	ValueSet	URI
Condition.code	required	TumorPathologyEventType http://ltsi.univ-rennes.fr/ValueSet/TumorPathologyEventType from this IG
Condition.bodySite	extensible	Topography http://ltsi.univ-rennes.fr/ValueSet/Topography from this IG
Condition.stage:morphology.summary	extensible	Morphology http://ltsi.univ-rennes.fr/ValueSet/Morphology from this IG

Name	Flags	Card.	Type	Description & Constraints
Condition	C	0..*	Condition	Detailed information about conditions, problems or diagnoses con-2: If category is problems list item, the clinicalStatus should not be unknown con-3: If condition is abated, then clinicalStatus must be either inactive, resolved, or remission.
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:due-to	S	0..1	Reference(Tumor Pathology Event)	The parent tumoral event URL: http://hl7.org/fhir/StructureDefinition/condition-dueTo profiled by http://ltsi.univ-rennes.fr/StructureDefinition/dueTo-tumor-pathology-event
extension:laterality	S	0..1	CodeableConcept	Laterality of location URL: http://ltsi.univ-rennes.fr/StructureDefinition/laterality Binding: Tumor Laterality Value Set (required)
extension:histologygrade	S	0..1	(Complex)	Histology of the tumor URL: http://ltsi.univ-rennes.fr/StructureDefinition/histologygrade
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
identifier	Σ	0..*	Identifier	External Ids for this condition
clinicalStatus	?!ΣC	1..1	CodeableConcept	active | recurrence | relapse | inactive | remission | resolved | unknown Binding: ConditionClinicalStatusCodes (required): The clinical status of the condition or diagnosis.
verificationStatus	?!Σ	0..1	CodeableConcept	unconfirmed | provisional | differential | confirmed | refuted | entered-in-error Binding: ConditionVerificationStatus (required): The verification status to support or decline the clinical status of the condition or diagnosis.
category	C	0..*	CodeableConcept	problem-list-item | encounter-diagnosis Binding: ConditionCategoryCodes (preferred): A category assigned to the condition.
severity		0..1	CodeableConcept	Subjective severity of condition Binding: ConditionDiagnosisSeverity (preferred): A subjective assessment of the severity of the condition as evaluated by the clinician.
code	SΣ	1..1	CodeableConcept	Type of tumor event Binding: Tumor Pathology Event Type Value Set (required)
bodySite	SΣ	1..1	CodeableConcept	Topographic code Binding: Topography Value Set (extensible)
subject	SΣ	1..1	Reference(OncoFAIR Patient)	Who has the condition?
encounter	Σ	0..1	Reference(Encounter)	The Encounter during which this Condition was created
Slices for onset[x]	Σ	1..1	dateTime	Estimated or actual date, date-time, or age Slice: Unordered, Closed by type:$this
onset[x]:onsetDateTime	SΣ	1..1	dateTime	Start date
Slices for abatement[x]	C	0..1	dateTime	When in resolution/remission Slice: Unordered, Closed by type:$this
abatement[x]:abatementDateTime	SC	0..1	dateTime	End date
recordedDate	SΣ	1..1	dateTime	Date of diagnosis
participant	Σ	0..*	BackboneElement	Who or what participated in the activities related to the condition and how they were involved
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
function	Σ	0..1	CodeableConcept	Type of involvement Binding: ParticipationRoleType (extensible)
actor	Σ	1..1	Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Device | Organization | CareTeam)	Who or what participated in the activities related to the condition
Slices for stage	C	1..*	BackboneElement	Stage/grade, usually assessed formally Slice: Unordered, Open by pattern:type.coding.code con-1: Stage SHALL have summary or assessment
stage:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
summary	C	0..1	CodeableConcept	Simple summary (disease specific) Binding: ConditionStage (example): Codes describing condition stages (e.g. Cancer stages).
assessment	C	0..*	Reference(ClinicalImpression | DiagnosticReport | Observation)	Formal record of assessment
type		0..1	CodeableConcept	Kind of staging Binding: ConditionStageType (example): Codes describing the kind of condition staging (e.g. clinical or pathological).
stage:morphology	SC	1..1	BackboneElement	International code of lesion / histological type / morphology of the tumoral event con-1: Stage SHALL have summary or assessment
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
summary	C	1..1	CodeableConcept	Histological/ morphological code Binding: Morphology Value Set (extensible)
assessment	C	0..*	Reference(ClinicalImpression | DiagnosticReport | Observation)	Formal record of assessment
type		0..1	CodeableConcept	Kind of staging Binding: ConditionStageType (example): Codes describing the kind of condition staging (e.g. clinical or pathological).
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	0..1	uri	Identity of the terminology system
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system Required Pattern: 116676008
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
evidence	Σ	0..*	CodeableReference(Resource)	Supporting evidence for the verification status Binding: SNOMEDCTClinicalFindings (example)
note		0..*	Annotation	Additional information about the Condition
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet	URI
Condition.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|5.0.0 from the FHIR Standard
Condition.clinicalStatus	required	ConditionClinicalStatusCodes http://hl7.org/fhir/ValueSet/condition-clinical|5.0.0 from the FHIR Standard
Condition.verificationStatus	required	ConditionVerificationStatus http://hl7.org/fhir/ValueSet/condition-ver-status|5.0.0 from the FHIR Standard
Condition.category	preferred	ConditionCategoryCodes http://hl7.org/fhir/ValueSet/condition-category from the FHIR Standard
Condition.severity	preferred	ConditionDiagnosisSeverity http://hl7.org/fhir/ValueSet/condition-severity from the FHIR Standard
Condition.code	required	TumorPathologyEventType http://ltsi.univ-rennes.fr/ValueSet/TumorPathologyEventType from this IG
Condition.bodySite	extensible	Topography http://ltsi.univ-rennes.fr/ValueSet/Topography from this IG
Condition.participant.function	extensible	ParticipationRoleType http://hl7.org/fhir/ValueSet/participation-role-type from the FHIR Standard
Condition.stage.summary	example	ConditionStage http://hl7.org/fhir/ValueSet/condition-stage from the FHIR Standard
Condition.stage.type	example	ConditionStageType http://hl7.org/fhir/ValueSet/condition-stage-type from the FHIR Standard
Condition.stage:morphology.summary	extensible	Morphology http://ltsi.univ-rennes.fr/ValueSet/Morphology from this IG
Condition.stage:morphology.type	example	ConditionStageType http://hl7.org/fhir/ValueSet/condition-stage-type from the FHIR Standard
Condition.evidence	example	SNOMEDCTClinicalFindings http://hl7.org/fhir/ValueSet/clinical-findings from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
con-1	error	Condition.stage, Condition.stage:morphology	Stage SHALL have summary or assessment : summary.exists() or assessment.exists()
con-2	warning	Condition	If category is problems list item, the clinicalStatus should not be unknown : category.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-category' and code='problem-list-item').exists() implies clinicalStatus.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-clinical' and code='unknown').exists().not()
con-3	error	Condition	If condition is abated, then clinicalStatus must be either inactive, resolved, or remission. : abatement.exists() implies (clinicalStatus.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-clinical' and (code='inactive' or code='resolved' or code='remission')).exists())
dom-2	error	Condition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	Condition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	Condition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	Condition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	Condition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Summary

Mandatory: 8 elements(1 nested mandatory element)
Must-Support: 10 elements

Structures

This structure refers to these other structures:

• OncoFAIR Patient (http://ltsi.univ-rennes.fr/StructureDefinition/oncofair-patient)

Extensions

This structure refers to these extensions:

• http://ltsi.univ-rennes.fr/StructureDefinition/dueTo-tumor-pathology-event
• http://ltsi.univ-rennes.fr/StructureDefinition/laterality
• http://ltsi.univ-rennes.fr/StructureDefinition/histologygrade

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of Condition.onset[x]
• The element 1 is sliced based on the value of Condition.abatement[x]
• The element 1 is sliced based on the value of Condition.stage

Name	Flags	Card.	Type	Description & Constraints
Condition	C	0..*	Condition	Detailed information about conditions, problems or diagnoses con-2: If category is problems list item, the clinicalStatus should not be unknown con-3: If condition is abated, then clinicalStatus must be either inactive, resolved, or remission. dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated dom-5: If a resource is contained in another resource, it SHALL NOT have a security label dom-6: A resource should have narrative for robust management
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created ele-1: All FHIR elements must have a @value or children
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
extension:due-to	S	0..1	Reference(Tumor Pathology Event)	The parent tumoral event URL: http://hl7.org/fhir/StructureDefinition/condition-dueTo profiled by http://ltsi.univ-rennes.fr/StructureDefinition/dueTo-tumor-pathology-event ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
extension:laterality	S	0..1	CodeableConcept	Laterality of location URL: http://ltsi.univ-rennes.fr/StructureDefinition/laterality Binding: Tumor Laterality Value Set (required) ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
extension:histologygrade	S	0..1	(Complex)	Histology of the tumor URL: http://ltsi.univ-rennes.fr/StructureDefinition/histologygrade ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
clinicalStatus	?!ΣC	1..1	CodeableConcept	active | recurrence | relapse | inactive | remission | resolved | unknown Binding: ConditionClinicalStatusCodes (required): The clinical status of the condition or diagnosis. ele-1: All FHIR elements must have a @value or children
verificationStatus	?!Σ	0..1	CodeableConcept	unconfirmed | provisional | differential | confirmed | refuted | entered-in-error Binding: ConditionVerificationStatus (required): The verification status to support or decline the clinical status of the condition or diagnosis. ele-1: All FHIR elements must have a @value or children
code	SΣ	1..1	CodeableConcept	Type of tumor event Binding: Tumor Pathology Event Type Value Set (required) ele-1: All FHIR elements must have a @value or children
bodySite	SΣ	1..1	CodeableConcept	Topographic code Binding: Topography Value Set (extensible) ele-1: All FHIR elements must have a @value or children
subject	SΣ	1..1	Reference(OncoFAIR Patient)	Who has the condition? ele-1: All FHIR elements must have a @value or children
Slices for onset[x]	Σ	1..1	dateTime	Estimated or actual date, date-time, or age Slice: Unordered, Closed by type:$this ele-1: All FHIR elements must have a @value or children
onset[x]:onsetDateTime	SΣ	1..1	dateTime	Start date ele-1: All FHIR elements must have a @value or children
Slices for abatement[x]	C	0..1	dateTime	When in resolution/remission Slice: Unordered, Closed by type:$this ele-1: All FHIR elements must have a @value or children
abatement[x]:abatementDateTime	SC	0..1	dateTime	End date ele-1: All FHIR elements must have a @value or children
recordedDate	SΣ	1..1	dateTime	Date of diagnosis ele-1: All FHIR elements must have a @value or children
Slices for stage	C	1..*	BackboneElement	Stage/grade, usually assessed formally Slice: Unordered, Open by pattern:type.coding.code con-1: Stage SHALL have summary or assessment ele-1: All FHIR elements must have a @value or children
stage:All Slices				Content/Rules for all slices
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
stage:morphology	SC	1..1	BackboneElement	International code of lesion / histological type / morphology of the tumoral event con-1: Stage SHALL have summary or assessment ele-1: All FHIR elements must have a @value or children
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
summary	C	1..1	CodeableConcept	Histological/ morphological code Binding: Morphology Value Set (extensible) ele-1: All FHIR elements must have a @value or children
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet	URI
Condition.clinicalStatus	required	ConditionClinicalStatusCodes http://hl7.org/fhir/ValueSet/condition-clinical|5.0.0 from the FHIR Standard
Condition.verificationStatus	required	ConditionVerificationStatus http://hl7.org/fhir/ValueSet/condition-ver-status|5.0.0 from the FHIR Standard
Condition.code	required	TumorPathologyEventType http://ltsi.univ-rennes.fr/ValueSet/TumorPathologyEventType from this IG
Condition.bodySite	extensible	Topography http://ltsi.univ-rennes.fr/ValueSet/Topography from this IG
Condition.stage:morphology.summary	extensible	Morphology http://ltsi.univ-rennes.fr/ValueSet/Morphology from this IG

Constraints

Id	Grade	Path(s)	Details	Requirements
con-1	error	Condition.stage, Condition.stage:morphology	Stage SHALL have summary or assessment : summary.exists() or assessment.exists()
con-2	warning	Condition	If category is problems list item, the clinicalStatus should not be unknown : category.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-category' and code='problem-list-item').exists() implies clinicalStatus.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-clinical' and code='unknown').exists().not()
con-3	error	Condition	If condition is abated, then clinicalStatus must be either inactive, resolved, or remission. : abatement.exists() implies (clinicalStatus.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-clinical' and (code='inactive' or code='resolved' or code='remission')).exists())
dom-2	error	Condition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	Condition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	Condition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	Condition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	Condition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Name	Flags	Card.	Type	Description & Constraints
Condition			Condition
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:due-to	S	0..1	Reference(Tumor Pathology Event)	The parent tumoral event URL: http://hl7.org/fhir/StructureDefinition/condition-dueTo profiled by http://ltsi.univ-rennes.fr/StructureDefinition/dueTo-tumor-pathology-event
extension:laterality	S	0..1	CodeableConcept	Laterality of location URL: http://ltsi.univ-rennes.fr/StructureDefinition/laterality Binding: Tumor Laterality Value Set (required)
extension:histologygrade	S	0..1	(Complex)	Histology of the tumor URL: http://ltsi.univ-rennes.fr/StructureDefinition/histologygrade
code	S	1..1	CodeableConcept	Type of tumor event Binding: Tumor Pathology Event Type Value Set (required)
bodySite	S	1..1	CodeableConcept	Topographic code Binding: Topography Value Set (extensible)
subject	S	1..1	Reference(OncoFAIR Patient)	Who has the condition?
Slices for onset[x]		1..1	dateTime	Estimated or actual date, date-time, or age Slice: Unordered, Open by type:$this
onset[x]:onsetDateTime	S	1..1	dateTime	Start date
Slices for abatement[x]		0..1	dateTime	When in resolution/remission Slice: Unordered, Open by type:$this
abatement[x]:abatementDateTime	S	0..1	dateTime	End date
recordedDate	S	1..1	dateTime	Date of diagnosis
Slices for stage		1..*	BackboneElement	Stage/grade, usually assessed formally Slice: Unordered, Open by pattern:type.coding.code
stage:morphology	S	1..1	BackboneElement	International code of lesion / histological type / morphology of the tumoral event
summary		1..1	CodeableConcept	Histological/ morphological code Binding: Morphology Value Set (extensible)
type
coding
code		1..1	code	Symbol in syntax defined by the system Required Pattern: 116676008
Documentation for this format

Terminology Bindings (Differential)

Path	Conformance	ValueSet	URI
Condition.code	required	TumorPathologyEventType http://ltsi.univ-rennes.fr/ValueSet/TumorPathologyEventType from this IG
Condition.bodySite	extensible	Topography http://ltsi.univ-rennes.fr/ValueSet/Topography from this IG
Condition.stage:morphology.summary	extensible	Morphology http://ltsi.univ-rennes.fr/ValueSet/Morphology from this IG

Name	Flags	Card.	Type	Description & Constraints
Condition	C	0..*	Condition	Detailed information about conditions, problems or diagnoses con-2: If category is problems list item, the clinicalStatus should not be unknown con-3: If condition is abated, then clinicalStatus must be either inactive, resolved, or remission.
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:due-to	S	0..1	Reference(Tumor Pathology Event)	The parent tumoral event URL: http://hl7.org/fhir/StructureDefinition/condition-dueTo profiled by http://ltsi.univ-rennes.fr/StructureDefinition/dueTo-tumor-pathology-event
extension:laterality	S	0..1	CodeableConcept	Laterality of location URL: http://ltsi.univ-rennes.fr/StructureDefinition/laterality Binding: Tumor Laterality Value Set (required)
extension:histologygrade	S	0..1	(Complex)	Histology of the tumor URL: http://ltsi.univ-rennes.fr/StructureDefinition/histologygrade
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
identifier	Σ	0..*	Identifier	External Ids for this condition
clinicalStatus	?!ΣC	1..1	CodeableConcept	active | recurrence | relapse | inactive | remission | resolved | unknown Binding: ConditionClinicalStatusCodes (required): The clinical status of the condition or diagnosis.
verificationStatus	?!Σ	0..1	CodeableConcept	unconfirmed | provisional | differential | confirmed | refuted | entered-in-error Binding: ConditionVerificationStatus (required): The verification status to support or decline the clinical status of the condition or diagnosis.
category	C	0..*	CodeableConcept	problem-list-item | encounter-diagnosis Binding: ConditionCategoryCodes (preferred): A category assigned to the condition.
severity		0..1	CodeableConcept	Subjective severity of condition Binding: ConditionDiagnosisSeverity (preferred): A subjective assessment of the severity of the condition as evaluated by the clinician.
code	SΣ	1..1	CodeableConcept	Type of tumor event Binding: Tumor Pathology Event Type Value Set (required)
bodySite	SΣ	1..1	CodeableConcept	Topographic code Binding: Topography Value Set (extensible)
subject	SΣ	1..1	Reference(OncoFAIR Patient)	Who has the condition?
encounter	Σ	0..1	Reference(Encounter)	The Encounter during which this Condition was created
Slices for onset[x]	Σ	1..1	dateTime	Estimated or actual date, date-time, or age Slice: Unordered, Closed by type:$this
onset[x]:onsetDateTime	SΣ	1..1	dateTime	Start date
Slices for abatement[x]	C	0..1	dateTime	When in resolution/remission Slice: Unordered, Closed by type:$this
abatement[x]:abatementDateTime	SC	0..1	dateTime	End date
recordedDate	SΣ	1..1	dateTime	Date of diagnosis
participant	Σ	0..*	BackboneElement	Who or what participated in the activities related to the condition and how they were involved
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
function	Σ	0..1	CodeableConcept	Type of involvement Binding: ParticipationRoleType (extensible)
actor	Σ	1..1	Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Device | Organization | CareTeam)	Who or what participated in the activities related to the condition
Slices for stage	C	1..*	BackboneElement	Stage/grade, usually assessed formally Slice: Unordered, Open by pattern:type.coding.code con-1: Stage SHALL have summary or assessment
stage:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
summary	C	0..1	CodeableConcept	Simple summary (disease specific) Binding: ConditionStage (example): Codes describing condition stages (e.g. Cancer stages).
assessment	C	0..*	Reference(ClinicalImpression | DiagnosticReport | Observation)	Formal record of assessment
type		0..1	CodeableConcept	Kind of staging Binding: ConditionStageType (example): Codes describing the kind of condition staging (e.g. clinical or pathological).
stage:morphology	SC	1..1	BackboneElement	International code of lesion / histological type / morphology of the tumoral event con-1: Stage SHALL have summary or assessment
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
summary	C	1..1	CodeableConcept	Histological/ morphological code Binding: Morphology Value Set (extensible)
assessment	C	0..*	Reference(ClinicalImpression | DiagnosticReport | Observation)	Formal record of assessment
type		0..1	CodeableConcept	Kind of staging Binding: ConditionStageType (example): Codes describing the kind of condition staging (e.g. clinical or pathological).
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	0..1	uri	Identity of the terminology system
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system Required Pattern: 116676008
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
evidence	Σ	0..*	CodeableReference(Resource)	Supporting evidence for the verification status Binding: SNOMEDCTClinicalFindings (example)
note		0..*	Annotation	Additional information about the Condition
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet	URI
Condition.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|5.0.0 from the FHIR Standard
Condition.clinicalStatus	required	ConditionClinicalStatusCodes http://hl7.org/fhir/ValueSet/condition-clinical|5.0.0 from the FHIR Standard
Condition.verificationStatus	required	ConditionVerificationStatus http://hl7.org/fhir/ValueSet/condition-ver-status|5.0.0 from the FHIR Standard
Condition.category	preferred	ConditionCategoryCodes http://hl7.org/fhir/ValueSet/condition-category from the FHIR Standard
Condition.severity	preferred	ConditionDiagnosisSeverity http://hl7.org/fhir/ValueSet/condition-severity from the FHIR Standard
Condition.code	required	TumorPathologyEventType http://ltsi.univ-rennes.fr/ValueSet/TumorPathologyEventType from this IG
Condition.bodySite	extensible	Topography http://ltsi.univ-rennes.fr/ValueSet/Topography from this IG
Condition.participant.function	extensible	ParticipationRoleType http://hl7.org/fhir/ValueSet/participation-role-type from the FHIR Standard
Condition.stage.summary	example	ConditionStage http://hl7.org/fhir/ValueSet/condition-stage from the FHIR Standard
Condition.stage.type	example	ConditionStageType http://hl7.org/fhir/ValueSet/condition-stage-type from the FHIR Standard
Condition.stage:morphology.summary	extensible	Morphology http://ltsi.univ-rennes.fr/ValueSet/Morphology from this IG
Condition.stage:morphology.type	example	ConditionStageType http://hl7.org/fhir/ValueSet/condition-stage-type from the FHIR Standard
Condition.evidence	example	SNOMEDCTClinicalFindings http://hl7.org/fhir/ValueSet/clinical-findings from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
con-1	error	Condition.stage, Condition.stage:morphology	Stage SHALL have summary or assessment : summary.exists() or assessment.exists()
con-2	warning	Condition	If category is problems list item, the clinicalStatus should not be unknown : category.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-category' and code='problem-list-item').exists() implies clinicalStatus.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-clinical' and code='unknown').exists().not()
con-3	error	Condition	If condition is abated, then clinicalStatus must be either inactive, resolved, or remission. : abatement.exists() implies (clinicalStatus.coding.where(system='http://terminology.hl7.org/CodeSystem/condition-clinical' and (code='inactive' or code='resolved' or code='remission')).exists())
dom-2	error	Condition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	Condition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	Condition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	Condition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	Condition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Summary

Mandatory: 8 elements(1 nested mandatory element)
Must-Support: 10 elements

Structures

This structure refers to these other structures:

• OncoFAIR Patient (http://ltsi.univ-rennes.fr/StructureDefinition/oncofair-patient)

Extensions

This structure refers to these extensions:

• http://ltsi.univ-rennes.fr/StructureDefinition/dueTo-tumor-pathology-event
• http://ltsi.univ-rennes.fr/StructureDefinition/laterality
• http://ltsi.univ-rennes.fr/StructureDefinition/histologygrade

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of Condition.onset[x]
• The element 1 is sliced based on the value of Condition.abatement[x]
• The element 1 is sliced based on the value of Condition.stage